Central administration of palmitoylethanolamide decreases hyperalgesia in mice by means of inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J PharmacolAll three experiments are consistent with present literature on PEA’s sizeable therapeutic index, which makes it an interesting prospect for the primary line therapy of joint p
2016a). This smaller raise was proportionate for the smaller peak of PEA levels detected in human volunteers when compared with beagle puppies. This variation, subsequently, might be caused by the reduced total quantity of PEA acutely administered to human volunteers (about ∼5 vs. 30 mg·kg−1 in pet dogs) and also to the fact that this was a m
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2015). These research, taken alongside one another, advise that, Despite the fact that a direct activation of GPR55 or PPAR‐α happens, PEA can produce its anti‐inflammatory motion inside the intestine also through indirect activation of CB1 and CB2 receptors, in all probability resulting from the ability of this compound to potentiate the moti
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